COG-E-352Homo sapiens (Human)Cancer cell line
Also known as: COGE352, CHLA352, CHLA-352
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_M153 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 17 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
| Subtype Features | EWS-ERG |
Disease Information
| Disease | Primitive neuroectodermal tumor |
|---|---|
| Lineage | Bone |
| Subtype | Ewing Sarcoma |
| OncoTree Code | ES |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001038_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg273His (c.818G>A) | Homozygous | - | Unknown, PubMed=16264262 |
| MutationSimple | STAG2 | p.Leu791fs | Unspecified | - | Unknown, PubMed=25010205 |
| Gene fusion | ERG | EWSR1-ERG, EWS-ERG | - | In frame | PubMed=9738976 |
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,11
D13S317
8,11
D16S539
9
D18S51
12
D19S433
14
D21S11
29,30
D2S1338
19,24
D3S1358
17
D5S818
10,13
D7S820
8,9
D8S1179
13,14
FGA
19
TH01
6,7
TPOX
8,11
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Harris E., Monks A., Morris J.
Mol. Cancer Ther. 14:2452-2462(2015).
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
PLoS Genet. 10:E1004475-E1004475(2014).
Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines.
Jenabi J., Ji L.-Y., Triche T.J., Lawlor E.R., Reynolds C.P.
PLoS ONE 8:E80060-E80060(2013).
Systematic multi-omics profiling of Ewing sarcoma cell lines.";
Orth M.F.
Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany.