Rh36Homo sapiens (Human)Cancer cell line
Also known as: BIRCH, Birch, RH-36, RH36
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_M599 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 15 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
Disease Information
| Disease | Embryonal rhabdomyosarcoma |
|---|---|
| Lineage | Soft Tissue |
| Subtype | Embryonal Rhabdomyosarcoma |
| OncoTree Code | ERMS |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001751_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | HRAS | p.Gln61Lys (c.181C>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11,12
D13S317
12,13
D16S539
11,13
D18S51
16
D19S433
14,15
D21S11
31,32
D2S1338
18
D3S1358
14,16
D5S818
13
D7S820
10,11
D8S1179
13
FGA
25
TH01
9.3
TPOX
8
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Surfaceome profiling of cell lines and patient-derived xenografts confirm FGFR4, NCAM1, CD276, and highlight AGRL2, JAM3, and L1CAM as surface targets for rhabdomyosarcoma.
Sala R., Heller M., Rossler J., Bernasconi M.
Int. J. Mol. Sci. 24:2601.1-2601.28(2023).
Proteomic profiling of rhabdomyosarcoma-derived exosomes yield insights into their functional role in paracrine signaling.
Diab-Assaf M., Saab R., Ghayad S.E.
J. Proteome Res. 18:3567-3579(2019).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Harris E., Monks A., Morris J.
Mol. Cancer Ther. 14:2452-2462(2015).
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Linardic C.M.
Front. Oncol. 3:183.1-183.12(2013).
Mutations of the BRAF gene in human cancer.";
Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Nature 417:949-954(2002).
Pediatric rhabdomyosarcoma cell lines are resistant to Fas-induced apoptosis and highly sensitive to TRAIL-induced apoptosis.
Petak I., Douglas L., Tillman D.M., Vernes R., Houghton J.A.
Clin. Cancer Res. 6:4119-4127(2000).