LPS141Homo sapiens (Human)Cancer cell line
Also known as: LS141
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_M823 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Dedifferentiated liposarcoma |
|---|---|
| Lineage | Soft Tissue |
| Subtype | Dedifferentiated Liposarcoma |
| OncoTree Code | DDLS |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001799_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
13
D16S539
12,14
D18S51
11,14
D21S11
28,29
D3S1358
17
D5S818
12
D7S820
11,12
D8S1179
11,13
FGA
23
Penta D
9,13
Penta E
11,12
TH01
9.3
TPOX
8,11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Harris E., Monks A., Morris J.
Mol. Cancer Ther. 14:2452-2462(2015).
Characterization of liposarcoma cell lines for preclinical and biological studies.
Munthe E., Myklebost O.
Sarcoma 2012:148614.1-148614.9(2012).
Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas.
Singer S.
Cancer Discov. 1:587-597(2011).
Restoration of C/EBPalpha in dedifferentiated liposarcoma induces G2/M cell cycle arrest and apoptosis.
Somberg C.J., Antonescu C.R., Singer S.
Genes Chromosomes Cancer 51:313-327(2012).
Small RNA sequencing and functional characterization reveals microRNA-143 tumor suppressor activity in liposarcoma.
Sander C., Tuschl T., Singer S.
Cancer Res. 71:5659-5669(2011).
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis.
O'Connor R.B., Moraco N.H., DeCarolis P.L., Antonescu C.R., Singer S.
Cancer Res. 71:2697-2705(2011).
ZIC1 overexpression is oncogenic in liposarcoma.";
Taylor B.S., Sander C., Koff A., Singer S.
Cancer Res. 70:6891-6901(2010).
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.
Cancer Res. 69:6941-6950(2009).