YUSIT1-B31Homo sapiens (Human)Cancer cell line

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_R737
SpeciesHomo sapiens (Human)
Tissue SourceNot specified

Disease Information

DiseaseMelanoma

DepMap Information

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleBRAFp.Val600Lys (c.1798_1799delGTinsAA)Heterozygous-from parent cell line YUSIT1

Publications

Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations.

Smitheman K.N., Dickerson S.H., Laquerre S.G., Liu L., Gilmer T.M.

Mol. Cancer Ther. 11:909-920(2012).