SNU-2535Homo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_R756 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 57 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Lung adenocarcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Lung Adenocarcinoma |
| OncoTree Code | LUAD |
DepMap Information
| Source Type | KCLB |
|---|---|
| Source ID | ACH-002531_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | ALK | p.Gly1269Ala (c.3806G>C) | Heterozygous | - | Unknown, PubMed=35852680, CelloPub=CLPUB00546 |
| Gene fusion | ALK | EML4-ALK | - | E6A20 v3 fusion | PubMed=35933914, PubMed=31882684 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
9,11
D16S539
9,11
D18S51
15
D19S433
10.2,14
D21S11
28,29
D2S1338
20,23
D3S1358
14,15
D5S818
10,12
D7S820
11
D8S1179
13,15
FGA
24,27
TH01
7,9.3
TPOX
11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Establishment of an acquired lorlatinib-resistant cell line of non-small cell lung cancer and its mediated resistance mechanism.
Zhang W.-M.
Clin. Transl. Oncol. 24:2231-2240(2022).