EWS-502Homo sapiens (Human)Cancer cell line
Also known as: EWS502, EWS/502
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_S740 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age Category | Pediatric |
|---|---|
| Sex | Unknown |
| Subtype Features | EWS-FLI |
Disease Information
| Disease | Ewing sarcoma |
|---|---|
| Lineage | Bone |
| Subtype | Ewing Sarcoma |
| OncoTree Code | ES |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000279_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys135Phe (c.404G>T) | Heterozygous | - | PubMed=22170099, PubMed=19147553, PubMed=16142320 |
| Gene fusion | EWSR1 | EWSR1-FLI1, EWS-FLI1 | - | Type 1 fusion | PubMed=15150091 |
Gene Expression Profile
Gene expression levels and statistical distribution
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Bradner J.E.
Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
Junction region of EWS-FLI1 fusion protein has a dominant negative effect in Ewing's sarcoma in vitro.
Jully B., Ramshankar V., Gopisetty G., Sabitha K., Rajkumar T.
BMC Cancer 12:513.1-513.10(2012).