SEMK2Homo sapiens (Human)Cancer cell line
Also known as: SEM-K2
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_S906 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 5 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
| Subtype Features | KMT2A |
Disease Information
| Disease | B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) |
|---|---|
| Lineage | Lymphoid |
| Subtype | B-Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3);KMT2A Rearranged |
| OncoTree Code | BLLKMT2A |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001735_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Gln (c.743G>A) | Unspecified | Somatic mutation acquired during proliferation | PubMed=20575032 |
| MutationSimple | CDKN2A | p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T) | Unspecified | - | PubMed=11787853 |
| Gene fusion | AFF1 | KMT2A-AFF1, MLL-AFF1, ALL-1/AF4 | - | In frame | from parent cell line SEMK2 |
Gene Expression Profile
Gene expression levels and statistical distribution
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