BIN-67Homo sapiens (Human)Cancer cell line
Also known as: BIN67, Bin-67
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_S987 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pelvis[UBERON:UBERON_0002355] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
Disease Information
| Disease | Small cell carcinoma of the ovary |
|---|---|
| Lineage | Ovary/Fallopian Tube |
| Subtype | Small Cell Carcinoma of the Ovary |
| OncoTree Code | SCCO |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001278_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | SMARCA4 | c.2439-2A>T | Heterozygous | Splice acceptor mutation | Unknown, PubMed=24658002 |
| MutationSimple | SMARCA4 | c.2438+1G>A | Heterozygous | Splice donor mutation | Unknown, PubMed=24658002 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,12
D13S317
10,12
D16S539
12
D18S51
13,19
D19S433
14,15.2
D21S11
30
D2S1338
17,25
D3S1358
15,19
D5S818
11,12
D7S820
9
D8S1179
14
FGA
22,23
TH01
6,9.3
TPOX
11
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.
Hasselblatt M., Majewski J., Foulkes W.D.
Nat. Genet. 46:438-443(2014).
Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics.
Vanderhyden B.C.
Orphanet J. Rare Dis. 8:33.1-33.14(2013).
Differential cyclic AMP responses to calcitonin among human ovarian carcinoma cell lines: a calcitonin-responsive line derived from a rare tumor type.
Upchurch K.S., Parker L.M., Scully R.E., Krane S.M.
J. Bone Miner. Res. 1:299-304(1986).