HCC2814Homo sapiens (Human)Cancer cell line
Also known as: Hamon Cancer Center 2814, HCC-2814
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_V586 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Lung squamous cell carcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Lung Squamous Cell Carcinoma |
| OncoTree Code | LUSC |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000690_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.His179Metfs*68 (c.535delC) | Homozygous | - | Unknown |
| MutationSimple | TP53 | p.Cys176Trp (c.528C>G) | Homozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
13
D13S317
10,11
D16S539
10,11,13
D18S51
12
D19S433
13,14
D21S11
29
D2S1338
24
D3S1358
17
D5S818
12
D7S820
10
D8S1179
15
FGA
24
Penta D
9
Penta E
10
TH01
6,8
TPOX
11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
Aldige C.R., Wistuba I.I., Minna J.D.
J. Cell. Biochem. 121:3986-3999(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Posner B.A., Minna J.D., Kim H.S., White M.A.
Cell 173:864-878.e29(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.
Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.
Br. J. Cancer 109:1599-1608(2013).