U-2946Homo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_X503 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 52 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Diffuse large B-cell lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Diffuse Large B-Cell Lymphoma, NOS |
| OncoTree Code | DLBCLNOS |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-002677_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | IGH | MYC-IGH | - | - | PubMed=31160637 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,11
D13S317
11,12
D16S539
11,12
D18S51
11,17
D19S433
12
D21S11
30
D2S1338
20,24
D3S1358
15,16
D5S818
11,12
D7S820
8,10
D8S1179
10,14
FGA
20,23
Penta D
9
Penta E
11
TH01
6,9.3
TPOX
9,12
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
The LL-100 panel: 100 cell lines for blood cancer studies.";
MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
Sci. Rep. 9:8218-8218(2019).
Diffuse large B cell lymphoma cell line U-2946: model for MCL1 inhibitor testing.
Uphoff C.C., Zaborski M., Berglund M., Enblad G., Amini R.-M.
PLoS ONE 11:E0167599-E0167599(2016).
Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.
Persson J.L., Wingren A.G.
Leuk. Lymphoma 48:2221-2232(2007).