HAP1Homo sapiens (Human)Cancer cell line
Also known as: HAP-1
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_Y019 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 40 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Subtype Features | BCR-ABL1 positive |
Disease Information
| Disease | Chronic myeloid leukemia |
|---|---|
| Lineage | Myeloid |
| Subtype | Chronic Myeloid Leukemia, BCR-ABL1+ |
| OncoTree Code | CMLBCRABL1 |
DepMap Information
| Source Type | Horizon Discovery |
|---|---|
| Source ID | ACH-002475_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Ser215Gly (c.643A>G) | Unspecified | - | PubMed=27693639 |
| Gene fusion | ABL1 | BCR-ABL1, BCR-ABL | - | BCR exon 1 fused to ABL1 exon 2 | PubMed=10576511, PubMed=10071072, PubMed=8751477 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D10S1248
15
D12S391
18
D13S317
11
D16S539
11
D18S51
18
D19S433
15
D1S1656
17.3
D21S11
30
D22S1045
16
D2S1338
25
D2S441
14
D3S1358
15
D5S818
12
D7S820
9
D8S1179
8,14
FGA
21
Penta D
9
Penta E
10
TH01
7
TPOX
8
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Efficient and crucial quality control of HAP1 cell ploidy status.";
Beigl T.B., Kjosas I., Seljeseth E., Glomnes N., Aksnes H.
Biol. Open 9:bio057174.1-bio057174.8(2020).
Biological plasticity rescues target activity in CRISPR knock outs.";
Bantscheff M., Steinmetz L.M., Drewes G., Huber W.
Nat. Methods 16:1087-1093(2019).
Proteogenomic analysis to identify missing proteins from haploid cell lines.
Superti-Furga G., Pandey A., Kandasamy R.K., Kim M.S.
Proteomics 18:1700386.1-1700386.9(2018).
Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.
Kralovics R., Brummelkamp T.R., Nijman S.M.B., Burckstummer T.
Genome Res. 24:2059-2065(2014).